Great Lakes NeuroTechnologies Awarded $2.1M NIH SBIR Grant for DBS Programming
Ohio Pen/10306960

INDEPENDENCE, Ohio - OhioPen -- Great Lakes NeuroTechnologies (GLNT) is excited to announce that it has been awarded a $2.1M Phase II SBIR grant ("DBS-Expert Pro: Automated Deep Brain Stimulation Programming Using Functional Mapping") from the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) to further develop its patented Kinesia™ technology for optimization of deep brain stimulation (DBS) for movement disorders such as Parkinson's disease (PD).

Dustin Heldman, Ph.D., is the principal investigator on the program. According to Dr. Heldman, "The clinical utility of DBS for the treatment of movement disorders such as Parkinson's disease has been well established; however, there is a great disparity in outcomes among DBS recipients due to varied postoperative management, particularly when choosing an optimal set of programming parameters from the thousands of possible combinations." Heldman continued, "The system we are developing will use our validated motion sensor-based assessments and algorithms to determine a set of programming parameters that optimize symptom improvement without causing side effects. In this program, we will also be integrating the system with commercial DBS platforms to enable efficient in-clinic and home-based DBS programming adjustments, which will reduce travel and help equalize care across the country."

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Zoltan Mari, M.D., director of the Parkinson's and Movement Disorders Program at Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, is a collaborator on the project serving as primary investigator at the Lou Ruvo Center for Brain Health. According to Dr. Mari, "Deep brain stimulation has become an essential therapy for many people with Parkinson's disease, yet programming remains complex and access to expert care is limited. This project will evaluate whether integrating objective, wearable-based monitoring with advanced algorithms can help guide programming decisions and expand access to care. If successful, the approach could standardize and improve DBS therapy while reducing barriers for patients who live far from specialty centers."

Also collaborating on the project is Dr. Vibhor Krishna, Associate Professor in the Department of Neurosurgery at the University of North Carolina School of Medicine. According to Dr. Krishna, "The technology enhancements in this program will take the DBS programming process to new heights of efficiency, benefiting patients in both clinical and home settings. By automating and standardizing the DBS programming process, we have the potential to significantly improve the quality of life for individuals with PD and other movement disorders."

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Dr. Heldman thanks the NIH, NINDS, and SBIR program for its continued support under this grant (Award Number R44NS143484). The content of this press release is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.